Clinical and morphological aspects of thin glomerular basement membrane disease.

نویسندگان

  • Jakub Zurawski
  • Wiesława Salwa-Zurawska
  • Aldona Woźniak
  • Elzbieta Bortkiewicz
  • Janusz Maciejewski
  • Ilona Idasiak-Piechocka
  • Bartosz Urbański
چکیده

The report presents the results of investigations carried out in 63 patients (49 children and 14 adults) with thin glomerular basement membrane disease. Of 49 children, 13 came from nine families with family members suffering from kidney diseases (mostly manifested by haematuria). In the group of children, the most frequent initial clinical symptom (noted in 29 cases) was isolated haematuria, more rarely (in eight cases) haematuria and proteinuria, and (in seven cases) nephrotic syndrome. Isolated proteinuria was observed in another three children. In the adults, only in five patients was isolated haematuria the initial symptom of the disease; more frequently (in seven cases), they presented with isolated proteinuria. In two patients, proteinuria and haematuria were noted. In the two groups of patients, in addition to markers of thin glomerular basement membrane disease, the authors also observed markers indicative of other glomerulopathies: in seven children and four adults focal segmental glomerulosclerosis (FSGS) without any other glomerular pathologies (with the exception of thin glomerular basement membrane disease). Also in cases in which in addition to thin glomerular basement membrane disease other glomerular pathologies were present (mesangial hypercellularity, mesangial glomerulonephritis), matrix expansion was detected; this phenomenon might be considered a harbinger of glomerular sclerosis. In general, although not in each and every case, these pathologies were associated with duration of the disease.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Thin basement membrane nephropathy and renal transplantation.

The clinical implications of thin basement membrane nephropathy (TBMN) in renal transplantation must be considered from the perspectives of both the allograft recipient and the donor. Most individuals with TBMN have a benign course, but some develop end-stage renal failure (ESRF) and undergo transplantation. ESRF in patients with TBMN often results from the presence of additional glomerular or ...

متن کامل

Basement membrane.

Basement membrane has attracted less attention than the other components of connective tissue. But, like the other extracellular fibres and matrix materials, it can profoundly influence both the structure and function of advanced life forms. Usually taking the shape of thin, structureless cementing material between epithelial and connective tissue, basement membranes are widely distributed thro...

متن کامل

Thin Glomerular Basement Membrane Disease (TGBM) in Bahrain– Light and Electronmicroscopic Study

Results: The age of patients ranged from 27-50 years with female predominance. There is family history of renal disease, haematuria, proteinuria and hypertension in two patients. One patient terminated in end stage renal disease. Light microscopy showed normal glomerular and tubulointerstitial compartment. Immunofluorescence studies were negative. EM confirmed the clinicopathological diagnosis ...

متن کامل

IgA nephropathy combined with thin basement membrane nephropathy in children

IgA Nephropathy (IgAN) and thin basement membrane nephropathy (TBMN) are the most common and important causes of persistent hematuria in childhood, and with great interest I have read the published article by Hwang et al [1] that appeared in a recent issue of Kidney Research and Clinical Practice entitled “Clinical manifestations of IgA nephropathy combined with thin glomerular basement membran...

متن کامل

Thin basement membrane nephropathy associated with other glomerular diseases.

Many reports confirm that thin basement membrane nephropathy (TBMN) commonly occurs together with other glomerular diseases such as minimal change glomerulonephritis, diabetes, membranous nephropathy, immunoglobulin (Ig)A glomerulonephritis, and focal segmental glomerulosclerosis. We postulate 3 explanations for these observations. The association of minimal change glomerulonephritis with TBMN ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Polish journal of pathology : official journal of the Polish Society of Pathologists

دوره 60 1  شماره 

صفحات  -

تاریخ انتشار 2009